| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:R-(+)-DIOA
CAS:81166-47-4
Purity:>=98% (HPLC), solid Package:10MG Remarks:D129-10MG
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| Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
info@efebio.com |
| Products Intro: |
Product Name:R-(+)-DIOA (R(+)-Butylindazone)
CAS:81166-47-4
Purity:98% (HPLC) Package:5mg;25mg
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Product Name:R-(+)-DIOA
CAS:81166-47-4
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| | R-(+)-DIOA Basic information |
| Product Name: | R-(+)-DIOA | | Synonyms: | R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid;Acetic acid, 2-[[(2R)-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl]oxy]- | | CAS: | 81166-47-4 | | MF: | C20H24Cl2O4 | | MW: | 399.31 | | EINECS: | | | Product Categories: | | | Mol File: | 81166-47-4.mol |  |
| | R-(+)-DIOA Chemical Properties |
| Melting point | 173-174 °C | | Boiling point | 562.2±50.0 °C(Predicted) | | density | 1.307±0.06 g/cm3(Predicted) | | solubility | H2O: insoluble <0.11mg/mL | | form | solid | | pka | 2.80±0.10(Predicted) | | color | white | | optical activity | [α]27/D +18.1°, c = 0.7 in methanol(lit.) |
| | R-(+)-DIOA Usage And Synthesis |
| Uses | R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system. | | Uses | R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
| | Biochem/physiol Actions | [(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system. |
| | R-(+)-DIOA Preparation Products And Raw materials |
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