| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
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| | AG 2263 Basic information |
| Product Name: | AG 2263 | | Synonyms: | AGL 2263;AG 2263;Benzenepropanenitrile, α-[(2,3-dihydro-2-oxo-5-benzoxazolyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-;AGL 2263,AGL2263 | | CAS: | 638213-98-6 | | MF: | C17H10N2O5 | | MW: | 322.27 | | EINECS: | | | Product Categories: | | | Mol File: | 638213-98-6.mol |  |
| | AG 2263 Chemical Properties |
| Melting point | 210 °C | | density | 1.541±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml | | form | A crystalline solid | | pka | 7.47±0.20(Predicted) | | color | Light yellow to yellow |
| | AG 2263 Usage And Synthesis |
| Uses | AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor[1][2]. | | References | [1] Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705. DOI:10.1073/pnas.1416675112
[2] Hua Zhang, et al. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Curr Biol. 2014 Nov 3;24(21):2501-8. DOI:10.1016/j.cub.2014.09.023
[3] Ying Han, et al. Insulin mitigates apoptosis of porcine follicular granulosa cells by downregulating BimEL. Reprod Biol. 2019 Sep;19(3):293-298. DOI:10.1016/j.repbio.2019.08.003 |
| | AG 2263 Preparation Products And Raw materials |
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