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4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)-

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4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:S1PR1 modulator 1
CAS:2328109-05-1
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:CAY10739
CAS:2328109-05-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:S1PR1 modulator 1;S-1PR1 modulator 1,S1PR1 modulator 1,inhibit,LPL Receptor,Lysophospholipid Receptor,Inhibitor
CAS:2328109-05-1
Purity:99.44% Package:1 mg;10 mg;100 mg;200 mg;25 mg;5 mg;50 mg
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:S1PR1 modulator 1
CAS:2328109-05-1
Purity:98% Package:5mg;10mg;25mg
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
Products Intro: Product Name:CAY10739
CAS:2328109-05-1
4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- Basic information
Product Name:4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)-
Synonyms:4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)-;S1PR1 modulator 1;S-1PR1 modulator 1,S1PR1 modulator 1,inhibit,LPL Receptor,Lysophospholipid Receptor,Inhibitor;(2Z,5Z)-5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-4-thiazolidinone
CAS:2328109-05-1
MF:C23H24N2O3S
MW:408.51
EINECS:
Product Categories:
Mol File:2328109-05-1.mol
4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- Structure
4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- Chemical Properties
Boiling point 542.1±60.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
solubility DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 5 mg/ml; Ethanol: 0.3 mg/ml
form A crystalline solid
pka0.08±0.20(Predicted)
Safety Information
MSDS Information
4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- Usage And Synthesis
DescriptionCAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 25.12 nM in a β-arrestin recruitment assay) that was designed to prevent systemic effects following topical application.1 It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively, in a β-arrestin recruitment assay). In human S9 skin subcellular fractions, an ester group that protects an unstable phenol group is cleaved to release the active soft drug. The active soft drug and its nonenzymatically formed isomers are rapidly metabolized in isolated human hepatocytes.
References1. Bell, M., Foley, D., Naylor, C., et al. Discovery of soft-drug topical tool modulators of sphingosine-1-phosphate receptor 1 (S1PR1) ACS Med. Chem. Lett. 10(3),341-347(2019).
4-Thiazolidinone, 5-[[4-(acetyloxy)-3-methylphenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)- Preparation Products And Raw materials
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