RF9
中文名称 | RF9 |
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中文同义词 | 神经肽FF受体拮抗剂RF9;化合物 T16738;N2-(金刚烷-1-基羰基)-L-精氨酰基-L-苯丙氨酰胺;2-金刚烷羰基-精氨酸-苯丙氨酸-NH2三氟乙酸酯(RF 9 TFA);RF9|||RF-9 |
英文名称 | 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE |
英文同义词 | 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE;2-Adamantanecarbonyl-Arg-Phe-NH2;RF 9;1-Adamantanecarbonyl-Arg-Phe-NH2;1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt;RF9 trifluoroacetate salt;RD9;L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl- |
CAS号 | 876310-60-0 |
分子式 | C26H38N6O3 |
分子量 | 482.62 |
EINECS号 | |
相关类别 | 标准品;目录肽 |
Mol文件 | 876310-60-0.mol |
结构式 |
RF9 性质
密度 | 1.42±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C |
溶解度 | H2O:可溶,20mg/mL |
酸度系数(pKa) | 14.53±0.20(Predicted) |
形态 | 固体 |
颜色 | 白色 |
hNPFF1R 58 nM (Ki) |
hNPFF2R 75 nM (Ki) |
RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.
RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance.
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9.
Animal Model: | Rats. |
Dosage: | 0.1 mg/kg. |
Administration: | S.C. 30 min before 0.3 mg/kg heroin or saline on basal nociceptive threshold in rats. |
Result: | Opposed to delaye heroin-induced hyperalgesia and associated tolerance. |
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-107382 | 2-ADAMANTANECARBONYL-ARG-PHE-NH2 RF9 | 876310-60-0 | 1mg | 990元 |
2024/08/19 | HY-107382 | 2-ADAMANTANECARBONYL-ARG-PHE-NH2 RF9 | 876310-60-0 | 5mg | 2900元 |