九聚精氨酸
| 中文名称 | 九聚精氨酸 |
|---|---|
| 中文同义词 | 九聚精氨酸;POLY ARGININE 9;(ARG)9游离态;(6S,9S,12S,15S,18S,21S,24S,27S,30S)-1,6-二氨基-9,12,15,18,21,24,27,30-八(3-胍基丙基)-1-亚氨基-7,10,13,16,19,22,25,28-八氧代-2,8,11,14,17,20,23,26,29-九氮杂三十一烷-31-酸;穿膜肽R9;(ARG)9;RRRRRRRRR;R9 ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG |
| 英文名称 | H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH |
| 英文同义词 | H-RRRRRRRRR-NH2;RRRRRRRRR;(ARG)9;H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH;Nonaarginine;H(-Arg)9-OH, Nonaarginine;(Arg)9 peptide;Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg |
| CAS号 | 143413-47-2 |
| 分子式 | C54H110N36O10 |
| 分子量 | 1423.69 |
| EINECS号 | |
| 相关类别 | 多肽;肽类中间体;目录多肽;目录肽;peptide |
| Mol文件 | 143413-47-2.mol |
| 结构式 |  |
九聚精氨酸 性质
| 密度 | 1.60±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 序列 | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH |
IC50: 0.78 μM (neuroprotection)
Poly-arginine (e.g. (Arg)9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM).
(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%