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3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide

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3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Suppliers list
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
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Products Intro: Product Name:CPTH6 HBr
CAS:2321332-57-2
Purity:98% Package:1mg;5mg;10mg
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
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Products Intro: Product Name:CPTH6 hydrobromide
CAS:2321332-57-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Cayman Chemical Company  
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Products Intro: Product Name:CPTH6 (hydrobromide)
CAS:2321332-57-2
Company Name: 1Pluschem LLC  
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Products Intro: CAS:2321332-57-2
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Products Intro: Product Name:3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide
CAS:2321332-57-2
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Basic information
Product Name:3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide
Synonyms:3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide
CAS:2321332-57-2
MF:
MW:0
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Mol File:Mol File
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Structure
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Chemical Properties
solubility DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 0.5 mg/ml
form A crystalline solid
Safety Information
MSDS Information
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Usage And Synthesis
DescriptionCPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP.1 It blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines.1 CPTH6 reduces cell viability, arresting cell cycling in the G0/G1 phase and inducing apoptosis.1 It impairs autophagy in a variety of tumor cell lines, at least in part by altering ATG7-mediated elongation of autophagosomal membranes.2
References1. Trisciuoglio, D., Ragazzoni, Y., Pelosi, A., et al. CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells Clin. Cancer Res. 18(2),475-486(2012).
2. Ragazzoni, Y., Desideri, M., Gabellini, C., et al. The thiazole derivative CPTH6 impairs autophagy Cell Death Dis. 4(3),e524(2013).
3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone,cyclopentanone,hydrobromide Preparation Products And Raw materials
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