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乙格列酯

乙格列酯 更多供应商
公司名称: BOC Sciences  
联系电话: 16314854226
产品介绍: 英文名称:Emiglitate
CAS:80879-63-6
纯度:98% 备注:Emiglitate is an α-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release.But no development was reported for the treatment of Diabetes mellitus
公司名称: 深圳市丽晶生化科技有限公司  
联系电话: 18938635012 0755-85201366
产品介绍: 英文名称:EMIGLITATE
CAS:80879-63-6
纯度:>98.0% 包装信息:10mg;100mg 备注:抑制剂进口标准品
公司名称: Dideu Industries Group Limited  
联系电话: 029-88380327
产品介绍: 英文名称:1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol USP/EP/BP
CAS:80879-63-6
纯度:99.9% 包装信息:1g;1.1USD 备注:FDA GMP CEP Approved Manufacturer
公司名称: Shaanxi Dideu Medichem Co. Ltd  
联系电话: 18192503167 +86-29-89586680
产品介绍: 英文名称:1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol USP/EP/BP
CAS:80879-63-6
纯度:99.9% 包装信息:25kgs/Drum;200kgs/Drum 备注:FDA GMP CEP Approved Manufacturer
公司名称: 上海陶术生物科技有限公司  
联系电话: 18019718960 781-999-5354
产品介绍: 英文名称:Emiglitate;BAY o 1248
CAS:80879-63-6
纯度:98.00% 包装信息:1 mg 备注:REAGENT;FOR LABORATORY USE ONLY
乙格列酯
生物活性体外研究体内研究
中文名称:乙格列酯
中文同义词:乙格列酯
英文名称:1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol
英文同义词:1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol;4-[2-[(2R,3R,4R,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)piperidino]ethoxy]benzoic acid ethyl ester;BAY-o-1248;MKC-542;Emiglitate;Benzoic acid, 4-[2-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]ethoxy]-, ethyl ester;1,5-dideoxy-1,5-[[2-[4-(ethoxycarbonyl)phenoxy]ethyl]imino]-D-glucitol USP/EP/BP
CAS号:80879-63-6
分子式:C17H25NO7
分子量:355.38
EINECS号:279-613-2
相关类别:
Mol文件:80879-63-6.mol
乙格列酯
乙格列酯 性质
沸点 580.2±50.0 °C(Predicted)
密度 1.328±0.06 g/cm3(Predicted)
酸度系数(pKa)13.68±0.70(Predicted)
乙格列酯 用途与合成方法
生物活性Emiglitate (BAY o 1248)是有效的,竞争选择性的α-glucoside hydrolase抑制剂。
体外研究

Emiglitate greatly suppresses the glucose-stimulated insulin release in parallel with an inhibitory effect on the activities of acid glucan-1,4-α-glucosidase and acid α-glucosidase. In contrast, the activities of acid phosphatase and N-acetyl-β-D-glucosaminidase tend to increase in the presence of the α-glucoside hydrolase inhibitor. The CO-induced amplification of the glucose-stimulated insulin release as well as of the increased activities of the acid α-glucoside hydrolases are abrogated by emiglitate and displayed the same levels as in the absence of CO. The CO-induced rise in the activities of acid phosphatase and acid N-acetyl-β-D-glucosaminidase is not appreciably affected by emiglitate.

体内研究

In fasted rats, emiglitate inducec a significant, dose-dependent increase of hepatic glycogen concentrations. The increase in hepatic glycogen is due to lysosomal storage of glycogen only. Emiglitate in the amount of 5 mg/kg b.wt. does not induce significant changes either of glycogen concentrations or at the EM-level.

安全信息
"乙格列酯" 相关产品信息()
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