|
ChemicalBook Optimization Suppliers |
| 名前: |
cjbscvictory Gold |
| 電話番号: |
13348960310 13348960310 |
| 電子メール: |
3003867561@qq.com |
| 名前: |
BOC Sciences |
| 電話番号: |
1-631-485-4226; 16314854226 |
| 電子メール: |
info@bocsci.com |
|
| | (-)-4,4'-[[(3aα,6aα)-テトラヒドロ-1H,3H-フロ[3,4-c]フラン]-1α,4α-ジイル]ビス(2-メトキシフェノール) 製品概要 |
| 化学名: | (-)-4,4'-[[(3aα,6aα)-テトラヒドロ-1H,3H-フロ[3,4-c]フラン]-1α,4α-ジイル]ビス(2-メトキシフェノール) | | 英語化学名: | (+)-PINORESINOL | | 别名: | (+)-PINORESINOL;(-)-4,4'-[[(3aα,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan]-1α,4α-diyl]bis(2-methoxyphenol);(3aS,6aS)-3a,4,6,6a-Tetrahydro-3β,6β-bis(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan;(3R,3aβ,6aβ)-3β,6β-Bis(3-methoxy-4-hydroxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan;2-Methoxy-4-[(1R)-4α-(3-methoxy-4-hydroxyphenyl)-3aα,4,6,6aα-tetrahydro-1H,3H-furo[3,4-c]furan-1α-yl]phenol;4,4'-[[(3aα,6aα)-Tetrahydro-1H,3H-furo[3,4-c]furan]-1α,4α-diyl]bis(2-methoxyphenol);(1S)-1β,4β-Bis(4-hydroxy-3-methoxyphenyl)-3aβ,4,6,6aβ-tetrahydro-1H,3H-furo[3,4-c]furan;(1β,5β)-2β,6β-Bis(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane | | CAS番号: | 487-36-5 | | 分子式: | C20H22O6 | | 分子量: | 358.39 | | EINECS: | | | カテゴリ情報: | Miscellaneous Natural Products | | Mol File: | 487-36-5.mol | ![(-)-4,4'-[[(3aα,6aα)-テトラヒドロ-1H,3H-フロ[3,4-c]フラン]-1α,4α-ジイル]ビス(2-メトキシフェノール)](CAS/GIF/487-36-5.gif) |
| | (-)-4,4'-[[(3aα,6aα)-テトラヒドロ-1H,3H-フロ[3,4-c]フラン]-1α,4α-ジイル]ビス(2-メトキシフェノール) 物理性質 |
| 融点 | 112 °C | | 沸点 | 556.5±50.0 °C(Predicted) | | 比重(密度) | 1.385 g/cm3 | | 貯蔵温度 | Sealed in dry,Room Temperature | | 溶解性 | DMSO: ≥6mg/mL | | 外見 | Solid | | 酸解離定数(Pka) | 9.54±0.35(Predicted) | | 色 | white to tan | | LogP | 1.591 (est) |
| | (-)-4,4'-[[(3aα,6aα)-テトラヒドロ-1H,3H-フロ[3,4-c]フラン]-1α,4α-ジイル]ビス(2-メトキシフェノール) Usage And Synthesis |
| 説明 | (+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties. It is an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 μM in Baker’s yeast and rat small intestine, respectively). (+)-Pinoresinol scavenges ABTS , but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; ), radicals in cell-free assays (IC50s = 13.43 and >200 μg/ml, respectively). It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC50 values of 29.35, 62.35, 75.32, >80, and >80 μM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 μM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 μM). | | 使用 | (+)-Pinoresinol is a lignan found in olive oil and in other plants. This phenolic compound was reported to have antioxidant and anticancer potential. | | 定義 | ChEBI: An enantiomer of pinoresinol having (+)-1S,3aR,4S,6aR-configuration. |
|