盐酸咪达普利
| 中文名称 | 盐酸咪达普利 |
|---|---|
| 中文同义词 | 咪达普利及其中间体;咪达普利盐酸盐;(S)-3-((S)-2-(((S)-1-乙氧基-1-氧代-4-苯基丁烷-2-基)氨基)丙酰基)-1-甲基-2-氧代咪唑啉-4-羧酸盐酸盐;盐酸咪达普利对照品 |
| 英文名称 | (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID |
| 英文同义词 | (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID;(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID: HYDROCHLORIDE;ACE/TA-6366;Novarok;SH-6366;Imidaprilhydrochloride;4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, (4S)-;4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, [4S-[3[R*(R*)],4R*]]- |
| CAS号 | 89396-94-1 |
| 分子式 | C20H27N3O6 |
| 分子量 | 405.44488 |
| EINECS号 | 685-551-0 |
| 相关类别 | 小分子抑制剂，天然产物;内分泌与激素;原料药;杂质对照品;化工原料;标准品;中药对照品;中间体;Inhibitors;医药原料 |
| Mol文件 | 89396-94-1.mol |
| 结构式 |  |
盐酸咪达普利 性质
| 熔点 | 214-216℃ |
|---|---|
| 比旋光度 | D20 -64.1° (c = 0.5 in ethanol) |
| 储存条件 | -20°C |
| 溶解度 | H2O：≥5mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至棕褐色 |
| 旋光性 (optical activity) | [α]/D -50 to -70° in ethanol (c=0.5) |
| Merck | 14,4911 |
Imidapril HCl是一种血管紧张素转换酶（ACE）抑制剂，IC50为2.6 nM，用于治疗高血压。
| Target | Value |
| ACE | 2.6 nM |
As a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | NI8927400 |
| 海关编码 | 2933.29.4300 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B1451 | Imidapril hydrochloride | 5 mg | 350元 | |
| 2024/01/25 | HY-B1451 | 盐酸咪达普利 Imidapril hydrochloride | 89396-94-1 | 10mg | 560元 |