| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Z164597606
CAS:1050587-57-9
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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Acetamide, 2-[(2-furanylmethyl)[(2-nitrophenyl)methyl]amino]-N-phenyl- manufacturers
- Z164597606
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- $1520.00 / 25mg
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2025-10-27
- CAS:1050587-57-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Acetamide, 2-[(2-furanylmethyl)[(2-nitrophenyl)methyl]amino]-N-phenyl- Basic information |
| | Acetamide, 2-[(2-furanylmethyl)[(2-nitrophenyl)methyl]amino]-N-phenyl- Chemical Properties |
| Boiling point | 547.7±45.0 °C(Predicted) | | density | 1.310±0.06 g/cm3(Predicted) | | pka | 13.90±0.70(Predicted) |
| | Acetamide, 2-[(2-furanylmethyl)[(2-nitrophenyl)methyl]amino]-N-phenyl- Usage And Synthesis |
| Uses | Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE). Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD)[1][2]. | | IC 50 | eqBCHE: 1.3 μM (IC50); hBCHE: 1.7 μM (IC50) | | References | [1] Xin Lu, et al. Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation. Bioorg Chem. 2019 Apr;85:117-127. DOI:10.1016/j.bioorg.2018.12.023
[2] Xin Lu, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729. DOI:10.1016/j.ejmech.2022.114729 |
| | Acetamide, 2-[(2-furanylmethyl)[(2-nitrophenyl)methyl]amino]-N-phenyl- Preparation Products And Raw materials |
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