| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PD 119819
CAS:105277-43-8
Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:PD-119819
CAS:105277-43-8
Purity:>98%
|
PD 119819 manufacturers
- PD 119819
-
- $2500.00 / 100mg
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2025-10-27
- CAS:105277-43-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | PD 119819 Basic information |
| Product Name: | PD 119819 | | Synonyms: | PD 119819;7-<3-<4-(2-pyridinyl)-1-piperazinyl>propoxy>-4H-1-benzopyran-4-one dihydrochloride;PD119819' PD-119819 | | CAS: | 105277-43-8 | | MF: | C21H24ClN3O3 | | MW: | 401.89 | | EINECS: | | | Product Categories: | | | Mol File: | 105277-43-8.mol |  |
| | PD 119819 Chemical Properties |
| | PD 119819 Usage And Synthesis |
| Description | PD 119819 is a heterocyclic piperazine and has been identified as an extremely selective DA autoreceptor agonist in tests that include [3H]haloperidol binding, inhibition of spontaneous locomotor activity, inhibition of brain DA synthesis, inhibition of brain DA neuronal firing, stereotypy assessment, and reversal of 6-hydroxydopamine (6-OHDA) induced akinesia in rats. | | Uses | PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2]. | | in vivo | PD 119819 (5~80 mg/kg; nasogastric intubation) makes monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values is evident after doses of 80 mg/kg[1]. | Animal Model: | Cynomolgus monkey[1] | | Dosage: | 5~80 mg/kg | | Administration: | Nasogastric intubation | | Result: | Made monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values were evident after doses of 80 mg/kg.
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| | IC 50 | Dopamine Receptor | | References | [1] Macallum GE, et al. Renal and hepatic toxicity of a benzopyran-4-one in the Cynomolgus monkey. Toxicology. 1989;59(1):97-108. DOI:10.1016/0300-483x(89)90159-5
[2] Jaen JC, et al. Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. J Med Chem. 1991;34(1):248-256. DOI:10.1021/jm00105a039 |
| | PD 119819 Preparation Products And Raw materials |
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