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| 化学名: | ガミスロマイシン | | 英語化学名: | Gamithromycin | | 别名: | GAMITHROMYCIN;(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-Cmethyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one;(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-7-propyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one;ML 1709460;(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-CMethyl-3-O-Methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-7-propyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadeca;(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-Cmethyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino;1-Oxa-7-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo;Gamithormycin | | CAS番号: | 145435-72-9 | | 分子式: | C40H76N2O12 | | 分子量: | 777.05 | | EINECS: | 604-472-4 | | カテゴリ情報: | Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 145435-72-9.mol |  |
| 融点 | >118°C (dec.) | | 沸点 | 833.0±65.0 °C(Predicted) | | 比重(密度) | 1.16±0.1 g/cm3(Predicted) | | 貯蔵温度 | under inert gas (nitrogen or Argon) at 2-8°C | | 溶解性 | Chloroform (Slightly), Methanol (Slightly) | | 酸解離定数(Pka) | 13.42±0.70(Predicted) | | 外見 | Solid | | 色 | White to Pale Yellow | | 安定性： | Hygroscopic | | CAS データベース | 145435-72-9(CAS DataBase Reference) |
| | ガミスロマイシン Usage And Synthesis |
| 効能 | 抗生物質 (獣医薬), タンパク質合成阻害薬 | | 化学的特性 | White to Off-White Solid | | 使用 | A macrolide compound which is known to have antibacterial activity, and is useful in the therapy of bacterial infections in mammals. Antibiotic. | | 使用 | Gamithromycin is a semi-synthetic macrocyclic lactone belonging to the azalide class derived from erthyromycin, typified by azithromycin. The synthesis of gamithromycin involves a ring expansion using a Beckmann rearrangement to produce the 15-membered dibasic macrolide. Gamithromycin provides a broader spectrum of action, higher acid stability and improved bioavailability compared to older analogues of the erythromycin class and has been exclusively developed for animal health applications. |
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