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| | talmapimod Basic information |
| Product Name: | talmapimod | | Synonyms: | talmapimod;6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-1H-indole-3-acetamide;Unii-B1E00kq6nt;6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamidehydrochloride;SCIO 469 hydrochloride;6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)Methyl]-2,5-diMethyl-1-piperazinyl]carbonyl]-N,N,1-triMethyl-α-oxo-1H-indole-3-acetaMide;SCIO 469;Scios 469 | | CAS: | 309913-83-5 | | MF: | C27H30ClFN4O3 | | MW: | 513 | | EINECS: | | | Product Categories: | | | Mol File: | 309913-83-5.mol |  |
| | talmapimod Chemical Properties |
| Boiling point | 658.0±65.0 °C(Predicted) | | density | 1.29 | | storage temp. | Desiccate at +4°C | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 6.52±0.70(Predicted) |
| | talmapimod Usage And Synthesis |
| Uses | Talmapimod is a p38 mitogen-activated protein (MAP) kinase inhibitor. Talmapimod reduced human myeloma cell growth in vivo both at early and advanced phases of the disease in mouse xenograft models. Talmapimod that blocks tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 synthesis in patients with active rheumatoid arthritis (RA) | | Definition | ChEBI: An indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,
-dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties. |
| | talmapimod Preparation Products And Raw materials |
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