|
|
| | CHEMBRDG-BB 5552132 Basic information |
| Product Name: | CHEMBRDG-BB 5552132 | | Synonyms: | CHEMBRDG-BB 5552132;(4-methoxybenzyl)(1-naphthylmethyl)amine(SALTDATA: HBr);(4-Methoxyphenyl)-N-(naphthalen-1-ylMethyl)MethanaMine;(4-Methoxyphenyl)-N-(naphthalen-1-ylMethyl)MethanaMine hcl;(4-METHOXYBENZYL)(1-NAPHTHYLMETHYL)AMINE;N-(4-Methoxybenzyl)-1-(naphthalen-1-yl)MethanaMine;N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine;1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]- | | CAS: | 185669-79-8 | | MF: | C19H19NO | | MW: | 277.36 | | EINECS: | | | Product Categories: | | | Mol File: | 185669-79-8.mol |  |
| | CHEMBRDG-BB 5552132 Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO: 10mg/mL, clear, colorless | | form | solid | | color | white | | InChI | 1S/C19H19NO/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17/h2-12,20H,13-14H2,1H3 | | InChIKey | GIFYKGIODMXYNT-UHFFFAOYSA-N | | SMILES | COC(C=C1)=CC=C1CNCC2=C(C=CC=C3)C3=CC=C2 |
| WGK Germany | WGK 2 | | Storage Class | 11 - Combustible Solids |
| | CHEMBRDG-BB 5552132 Usage And Synthesis |
| Uses | A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, Kir2.1 (IC50 = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the Kir2.x family, but has no effect on Kir1.1 (IC50 >300 µM) and displays weak activity for Kir4.1 and Kir7.1 (IC50 = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on Kir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters. | | Definition | ChEBI: 1-(4-methoxyphenyl)-N-(1-naphthalenylmethyl)methanamine is a member of naphthalenes. |
| | CHEMBRDG-BB 5552132 Preparation Products And Raw materials |
|