盐酸阿曲生坦
| 中文名称 | 盐酸阿曲生坦 |
|---|---|
| 中文同义词 | (2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐;盐酸阿曲生坦;阿曲生坦盐酸盐;(2R,3R,4S)-4-(苯并[D][1,3]二氧杂环-5-基)-1-(2-(二丁基氨基)-2-氧乙基)-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐 |
| 英文名称 | Atrasentan hydrochloride |
| 英文同义词 | Atrasentan hydrochloride;3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R,3R,4S)-;A 147627.1;Abbott 147627;Atrasentan HCl;Atrasentan hydrochloride [usan];Unii-E4G31X93za;ABT 627 |
| CAS号 | 195733-43-8 |
| 分子式 | C29H38N2O6.HCl |
| 分子量 | 547.08 |
| EINECS号 | |
| 相关类别 | Amines;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 195733-43-8.mol |
| 结构式 |  |
盐酸阿曲生坦 性质
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
| InChIKey | IJFUJIFSUKPWCZ-FZVADPAUNA-N |
| SMILES | C1(=CC2=C(OCO2)C=C1)[C@@H]1[C@@H](C(=O)O)[C@H](C2C=CC(OC)=CC=2)N(CC(N(CCCC)CCCC)=O)C1.Cl |&1:9,10,14,r| |
IC50: 0.055 nM (ET A )
Atrasentan hydrochloride (ABT-627 hydrochloride) (0-50 μM) significantly inhibits LNCaP and C4-2b prostate cancer cell growth. Atrasentan profoundly induces several CYPs and drug transporters (e.g. 12-fold induction of CYP3A4 at 50 μM). It is a moderate P-gp inhibitor (IC 50 in P388/dx cells=15.1±1.6 μM) and a weak BCRP inhibitor (IC 50 in MDCKII-BCRP cells=59.8±11 μM).
Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-15403A | Atrasentan hydrochloride | 1 mg | 545元 | |
| 2024/01/25 | HY-15403A | (2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐 Atrasentan hydrochloride | 195733-43-8 | 5mg | 1200元 |