阿戈美拉汀杂质
| 中文名称 | 阿戈美拉汀杂质 |
|---|---|
| 中文同义词 | 3-羟基阿戈美拉汀;阿戈美拉汀杂质37;阿戈美拉汀3-羟基杂质 |
| 英文名称 | 3-Hydroxy Agomelatine |
| 英文同义词 | N-(2-(3-Hydroxy-7-methoxynaphthalen-1-yl)ethyl)acetamide;Acetamide, N-[2-(3-hydroxy-7-methoxy-1-naphthalenyl)ethyl]-;Agomelatine Impurity 37;Agomelatine 3-Hydroxy Impurity;Agomelatine impurity 1/3-Hydroxy Agomelatine/N-[2-(3-Hydroxy-7-methoxy-1-naphthalenyl)ethyl]acetamide;N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide;3-Hydroxyagomelatine |
| CAS号 | 166526-99-4 |
| 分子式 | C15H17NO3 |
| 分子量 | 259.3 |
| EINECS号 | |
| 相关类别 | 杂质对照品 |
| Mol文件 | 166526-99-4.mol |
| 结构式 |  |
阿戈美拉汀杂质 性质
| 沸点 | 545.8±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.190±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 9.85±0.40(Predicted) |
|
5-HT 2C Receptor 3.2 μM (IC 50 ) |
5-HT 2C Receptor 1.8 μM (Ki) |
Agomelatine and S 21517 have moderately high affinities for 5-HT 2C receptors ( K i = 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity ( K i = 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10 -7 -10 -4 M) are antagonists at 5-HT 2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine.
Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-133111 | 3-羟基阿戈美拉汀D3 3-Hydroxy agomelatine | 166526-99-4 | 5mg | 1700元 |
| 2024/01/25 | HY-133111 | 3-Hydroxy agomelatine | 10 mM * 1 mLin DMSO | 1870元 |