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| | Gemcitabine monophosphate Basic information |
| Product Name: | Gemcitabine monophosphate | | Synonyms: | Gemcitabine monophosphate disodium salt;Gemcitabine monophosphate disodium;GEMCITABINE MONOPHOSPHATE DISODIUM SALT MONOHYDRATE; GEMCITABINE MONOPHOSPHATE DISODIUM; GEMMP;GemMP;Gemcitabine monophosphate disodium monohydrate;4-amino-1-((2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one, phosphate salt | | CAS: | 1638288-31-9 | | MF: | C9H13F2N3NaO7P | | MW: | 367.18 | | EINECS: | | | Product Categories: | | | Mol File: | 1638288-31-9.mol |  |
| | Gemcitabine monophosphate Chemical Properties |
| storage temp. | Store at 0-8 °C | | solubility | DMSO:10.0(Max Conc. mg/mL);24.68(Max Conc. mM) |
| | Gemcitabine monophosphate Usage And Synthesis |
| Uses | Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles[1][2]. | | in vivo | Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1]. | Animal Model: | Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1] | | Dosage: | 19.5 mg/kg, every other day, four injections | | Administration: | Intravenous injection (i.v.) | | Result: | Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis. |
| | References | [1] Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. DOI:10.1038/mt.2013.120
[2] Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. DOI:10.1002/adfm.201401076 |
| | Gemcitabine monophosphate Preparation Products And Raw materials |
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