辛伐他汀钠盐
中文名称 | 辛伐他汀钠盐 |
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中文同义词 | 羟基辛伐他汀酸钠;辛伐他汀羟基酸钠盐-D6;辛伐他汀钠盐;辛伐他汀羟基酸钠盐;辛伐他汀杂质A;辛伐他汀杂质A(EP) 标准品;辛伐他汀杂质01(NA);辛伐他汀EP杂质钠盐 |
英文名称 | SIMVASTATIN, SODIUM SALT |
英文同义词 | SIMVASTATIN HYDROXY ACID SODIUM SALT;SIMVASTATIN, SODIUM SALT;IMp. A (EP) as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt;Simvastatin Impurity as Sodium Salt;Simvastati;SiMvastatin IMp. A (EP) as SodiuM Salt;sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate;Simvastatin hydroxyl acid sodium salt-d6 |
CAS号 | 101314-97-0 |
分子式 | C25H41NaO6 |
分子量 | 460.59 |
EINECS号 | |
相关类别 | 168- 辛伐他汀;杂质对照品 |
Mol文件 | Mol File |
结构式 |
辛伐他汀钠盐 性质
熔点 | >122°C (dec.) |
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储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
溶解度 | DMSO(少许)、甲醇(少许)、水(少许) |
形态 | 白色粉末状固体。 |
颜色 | 白色至浅棕色 |
稳定性 | 吸湿性 |
Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts.Simvastatin sodium (100 μM) inhibits the Na + /H + antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene.
Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia.