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| | 2-PHENYL-PYRIDIN-4-YLAMINE Basic information |
| | 2-PHENYL-PYRIDIN-4-YLAMINE Chemical Properties |
| Boiling point | 384.2±30.0 °C(Predicted) | | density | 1.133±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 8.22±0.10(Predicted) | | form | solid | | color | Pale yellow |
| Risk Statements | 41 | | Safety Statements | 26-39 | | HS Code | 2933399990 |
| | 2-PHENYL-PYRIDIN-4-YLAMINE Usage And Synthesis |
| Uses | 2-PPA is a selective inhibitor of TMEM175 (IC50=32 μM) with activity in modulating lysosomal function. Acute inhibition of TMEM175 by 2-PPA increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. 2-PPA can be used in the study of Parkinson's disease[1]. | | References | [1] SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024). DOI:10.1021/jacs.4c05623 |
| | 2-PHENYL-PYRIDIN-4-YLAMINE Preparation Products And Raw materials |
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