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| 化学名: | ベシゴムシン | | 英語化学名: | Gomisin A | | 别名: | 2,3,13-tetramethoxy-l-stereoisomer;benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol,5,6,7,8-tetrahydro-6,7-dimethy;wuweizialcoholb;wuweizichunb;BESIGOMISIN;GOMISIN A;SCHISANDROL B;SCHIZANDROL B | | CAS番号: | 58546-54-6 | | 分子式: | C23H28O7 | | 分子量: | 416.47 | | EINECS: | | | カテゴリ情報: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products | | Mol File: | 58546-54-6.mol |  |
| 融点 | 88.5°C | | 沸点 | 454.79°C (rough estimate) | | 比重(密度) | 1.1772 (rough estimate) | | 屈折率 | 1.5300 (estimate) | | 貯蔵温度 | Sealed in dry,Store in freezer, under -20°C | | 溶解性 | DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | | 外見 | powder to crystal | | 酸解離定数(Pka) | 14.58±0.40(Predicted) | | 色 | White to Light yellow | | LogP | 4.770 (est) |
| Sフレーズ | 24/25 | | HSコード | 29329990 |
| | ベシゴムシン Usage And Synthesis |
| 外観 | 白色〜わずかにうすい褐色, 結晶性粉末〜粉末 | | 溶解性 | アセトニトリルに溶ける。 | | 用途 | 局方収載ゴミシ有効成分の確認試験用。 | | 効能 | 肝保護薬 | | 使用上の注意 | 不活性ガス封入 | | 説明 | Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen . | | 化学的特性 | White powder | | 使用 | Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect. |
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