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| 化学名: | クロルスロン | | 英語化学名: | Clorsulon | | 别名: | 4-amino-6-(trichloroethenyl)-3-benzenedisulfonamide;curatrem;l631529;4-AMINO-6-(TRICHLORO-ETHENYL)-1,3-BENZENEDISULFONAMIDE;4-AMINO-6-TRICHLOROVINYL-1,3-BENZENEDISULFONAMIDE;4-AMINO-6-(TRICHLOROVINYL)-M-BENZENEDISULFONAMIDE;1,3-Benzenedisulfonamide, 4-amino-6-(trichloroethenyl)-;4-AMINO-6-(TRICHLOROETHENYL)-1,3-BENZENEDISULPHONAMIDE | | CAS番号: | 60200-06-8 | | 分子式: | C8H8Cl3N3O4S2 | | 分子量: | 380.66 | | EINECS: | 262-100-2 | | カテゴリ情報: | ZOMAX;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds | | Mol File: | 60200-06-8.mol |  |
| 融点 | 194-203°C | | 沸点 | 651.7±65.0 °C(Predicted) | | 比重(密度) | 1.800±0.06 g/cm3(Predicted) | | 貯蔵温度 | Keep in dark place,Inert atmosphere,2-8°C | | 溶解性 | DMSO (Slightly), Methanol (Slightly) | | 酸解離定数(Pka) | 9.16±0.60(Predicted) | | 色 | White | | CAS データベース | 60200-06-8(CAS DataBase Reference) |
| Sフレーズ | 24/25 | | WGK Germany | 2 | | RTECS 番号 | CZ9090000 | | HSコード | 29350090 | | 毒性 | LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind) |
| | クロルスロン Usage And Synthesis |
| 外観 | 白色, 結晶性粉末〜粉末 | | 溶解性 | エタノール及びアセトンに溶け、水にほとんど溶けない。 | | 効能 | 抗寄生虫薬 (肝吸虫) | | 説明 | Clorsulon is a sulfonamide antiparasitic agent. It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 μg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection. It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg. Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle. | | 化学的特性 | Crystalline Solid | | 使用 | A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes). | | 使用 | analgesic, antiinflammatory | | 定義 | ChEBI: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide is a sulfonamide and a member of benzenes. | | brand name | Curatrem [Veterinary] (Merial). | | Veterinary Drugs and Treatments | Clorsulon is approved for use in the treatment of immature and
adult forms of Fasciola hepatica (Liver fluke) in cattle. It is not effective
against immature flukes less than 8 weeks old. It also has activity
against Fasciola gigantica. Although not approved, the drug has
been used in practice in various other species (e.g., sheep, llamas).
It has activity against F. magna in sheep, but is not completely effective
in eradicating the organism after a single dose, thus severely
limiting its clinical usefulness against this parasite. Clorsulon is also
not effective against the rumen fluke (Paramphistomum). |
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