阿奇霉素二水物
| 中文名称 | 阿奇霉素二水物 |
|---|---|
| 中文同义词 | 9-脱氧-9a-氮杂-9a-红霉素A;阿奇霉素二水合物;阿齐霉素 二水合物;阿奇霉素(标准品);阿奇霉素二水物;阿奇霉素二水合物 标准品;A116-阿奇霉素二水物;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(二甲基胺基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-2-乙基-3,4,10-三羟基-13-(((2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基)氧基]-3,5,6,8,10,12,14-七甲基-1-氧杂-6-氮杂环十五烷-15-酮二水合物 |
| 英文名称 | Azithromycin dihydrate |
| 英文同义词 | AZITHROMYCIN 2-HYDRATE;1-Oxa-6-azacyclopentadecan-15-one, 13-(2,6-dideoxy-3-C-methyl-3-O-methyl-.alpha.-L-ribo-hexopyranosyl)oxy-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-3,4,6-trideoxy-3-(dimethylamino)-.beta.-D-xylo-hexopyranosyloxy-, dihydrate, (2R,3S,4R,5R,8;AZITHROMYCINDIHYDRATE(PATENTED-NOSUPPLY);1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, dihydrate, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-;azithromycin hydrate;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one Dihydrate;N-METHYL-11,AZA-10,DEOXO-10, DIHYDROERYTHROMYcIN A DIHYDRATE;Azithromycin (100 mg) |
| CAS号 | 117772-70-0 |
| 分子式 | C38H74N2O13 |
| 分子量 | 767.01 |
| EINECS号 | 641-134-5 |
| 相关类别 | 医药原料;抗生素;小分子抑制剂，天然产物;小分子抑制剂;原料药;药物杂质及中间体;化工原料;通用生化试剂-抗生素;Macrolides (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals;SELDANE;Inhibitors;化学原料 |
| Mol文件 | 117772-70-0.mol |
| 结构式 |  |
阿奇霉素二水物 性质
| 熔点 | 126 C |
|---|---|
| 沸点 | 717℃ |
| 比旋光度 | D26 -41.4° (c = 1 in CHCl3) |
| RTECS号 | RN6960000 |
| 折射率 | -47 ° (C=2, EtOH) |
| 闪点 | >110°(230°F) |
| 储存条件 | room temp |
| 溶解度 | 溶于 DMSO，浓度为 20mg/ml。也溶于氯仿或二氯乙烷 |
| 形态 | 粉末 |
| 颜色 | 米白色 |
| 敏感性 | Air Sensitive |
| Merck | 14,915 |
| EPA化学物质信息 | 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-?-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-D-xylo-hexopyranosyl]oxy]-, dihydrate, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- (117772-70-0) |
Azithromycin显示抗一系列相似谱的菌体活性。Azithromycin体外作用于革兰氏阳性菌其活性略低于红霉素，随着易感浓度下降到组织Azithromycin的浓度范围内，尽管这在临床意义上不确定。Azithromycin对红霉素的易感/ βL-ve 株, Streptococcus 株和 NS (非选择性抗敏感菌)/的平均MIC90分别为0.63, 0.35, 和<0.27 mg/L。相比之下，Azithromycin作用于大多革兰阴性菌和其他一些病原体的活性似乎比红霉素更强，特别是 Haemophilus influenza (MIC90, 1.34 mg/L), H. parainfluenzae (MIC90, 1 mg/L), Moraxella catarrhalis (MIC90, <0.1 mg/L), Neisseria gonorrhoeae (MIC90, 0.25 mg/L), Ureaplasma urealyticum , Bordetella spp (MIC90, 0.03-0.24 mg/L) 和 Borrelia burgdorferi 。Azithromycin也抗临床分离株厌氧革兰氏阳性菌 cocci 和 propionibacterium acnes 的活性，其MIC90为 2.3, 0.03 mg/L。像红霉素和其他大分子霉素一样，Azithromycin的活性不受β-内酰胺酶产生的影响。然而，红霉素耐药菌也耐Azithromycin。
Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 24/25-36/37/39 |
| WGK Germany | 3 |
| 海关编码 | 29419000 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-17506A | 阿奇霉素二水物 Azithromycin hydrate | 117772-70-0 | 50 mg | 800元 |
| 2024/01/25 | HY-17506A | 阿奇霉素二水物 Azithromycin hydrate | 117772-70-0 | 100 mg | 1250元 |