| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CCG 232601
CAS:1922099-21-5
Purity:99% Remarks:CCG 232601 is a selective and orally bioactive inhibitor of the Rho/MRTF/SRF signaling pathway (IC50 value of 0.55 μM (SRE.L assay)) as a potential antifibrotic therapeutic for systemic scleroderma. C
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:CCG-232601
CAS:1922099-21-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CCG-232601
CAS:1922099-21-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | CCG-232601 Basic information |
| Product Name: | CCG-232601 | | Synonyms: | CCG-232601;CCG-232601
(CCG232601);3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl)benzoyl]-;N-(4-chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl)benzoyl]-3-piperidinecarboxamide | | CAS: | 1922099-21-5 | | MF: | C24H20ClF2N3O2 | | MW: | 455.88 | | EINECS: | | | Product Categories: | | | Mol File: | 1922099-21-5.mol |  |
| | CCG-232601 Chemical Properties |
| Boiling point | 683.1±55.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml | | form | A crystalline solid | | pka | 13.69±0.70(Predicted) |
| | CCG-232601 Usage And Synthesis |
| Description | CCG-232601 is an inhibitor of the Rho/MRTF/SRF transcriptional pathway and a derivative of CCG-203971 . CCG-232601 inhibits MRTF-dependent transcription in HEK293T cells (IC50 = 0.55 μM in a luciferase reporter assay). It also reduces expression of α-smooth muscle actin (α-SMA) in TGF-β-stimulated human dermal fibroblasts to 31% of control when used at a concentration of 10 μM. CCG-232601 (50 mg/kg) inhibits increases in dermal thickness and hydroxyproline content in a mouse model of dermal fibrosis induced by bleomycin . |
| | CCG-232601 Preparation Products And Raw materials |
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