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| | 5,6-ジヒドロ-2,3,9,10-テトラメトキシジベンゾ[a,g]キノリジニウム·クロリド 製品概要 |
| 化学名: | 5,6-ジヒドロ-2,3,9,10-テトラメトキシジベンゾ[a,g]キノリジニウム·クロリド | | 英語化学名: | Palmatine chloride | | 别名: | 2,3,9,10-TETRAMETHOXYPROTOBERBERINCHLORIDE;BERBERICINE CHLORIDE;PALMATINE CHLORIDE;Palmatine HCL;PalMatin hydrochloride;2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride;Palmatine chloride
2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride;(947153-64-2) palmatine chloride | | CAS番号: | 10605-02-4 | | 分子式: | C21H22ClNO4 | | 分子量: | 387.86 | | EINECS: | | | カテゴリ情報: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors | | Mol File: | 10605-02-4.mol | ![5,6-ジヒドロ-2,3,9,10-テトラメトキシジベンゾ[a,g]キノリジニウム·クロリド](CAS/GIF/10605-02-4.gif) |
| | 5,6-ジヒドロ-2,3,9,10-テトラメトキシジベンゾ[a,g]キノリジニウム·クロリド 物理性質 |
| 融点 | 205℃ | | 貯蔵温度 | Hygroscopic, Refrigerator, under inert atmosphere | | 溶解性 | Chloroform (Slightly), DMSO (Slightly) | | 外見 | Solid | | 色 | Yellow | | InChI | InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1 | | InChIKey | RLQYRXCUPVKSAW-UHFFFAOYSA-M | | SMILES | C12=CC3=C(C(OC)=C(OC)C=C3)C=[N+]1CCC1C=C(OC)C(OC)=CC2=1.[Cl-] |
| | 5,6-ジヒドロ-2,3,9,10-テトラメトキシジベンゾ[a,g]キノリジニウム·クロリド Usage And Synthesis |
| 外観 | 黄色〜黄褐色, 結晶〜結晶性粉末 | | 溶解性 | 熱湯,エタノールに可溶。 | | 用途 | 薬理研究用。 | | 使用上の注意 | アルゴン封入 | | 説明 | Corydalis paUida yields this alkaloid which occurs in the quaternary base fraction.
The alkaloid is separated by droplet countercurrent chromatography and crystallizes from H20 as yellow-green needles. | | 説明 | Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 μM, respectively). Palmatine (20, 40, and 80 μM) reduces Zika virus infection of Vero cells in a concentration-dependent manner. In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; ). It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers. Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia. | | 使用 | antibacterial, antimalarial, uterine contractant | | 使用 | Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent. | | target | Antifection | | 参考文献 | Tani, Nakagura, Hattori, Yakugaku Zasshi, 95, 1103 (1975) |
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