GT 949 manufacturers
- GT 949
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- $48.00 / 10mg
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2025-11-09
- CAS:460330-27-2
- Min. Order:
- Purity: 99.95%
- Supply Ability: 10g
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| Product Name: | GT 949 | | Synonyms: | GT 949;3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one;2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-;GT 949, 10 mM in DMSO | | CAS: | 460330-27-2 | | MF: | C30H37N7O2 | | MW: | 527.66 | | EINECS: | | | Product Categories: | | | Mol File: | 460330-27-2.mol |  |
| | GT 949 Chemical Properties |
| Boiling point | 770.7±60.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mM; Ethanol: 10 mM, heated | | form | A solid | | pka | 10.55±0.70(Predicted) | | color | Off-white to light yellow |
| | GT 949 Usage And Synthesis |
| Uses | GT 949 is a selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Increases glutamate removal by 70%. Exhibits no effect on DAT, SERT and NET or NMDA receptors. | | Biological Activity | GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC50 = 0.26 nM; COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3. GT949 enhances glutamate uptake of cultured r at astrocytes (EC50 = 1 nM, Emax = 158%) with no potency toward human serotonin (SERT), noradrenaline (NET) and dopamine (DAT) transporters, nor NMDA receptors (murine primary cortical neurons). | | IC 50 | EAAT2 | | storage | Store at -20°C |
| | GT 949 Preparation Products And Raw materials |
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