PIM1-IN-1 manufacturers
- PIM1-IN-1
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- $2360.00 / 100mg
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2025-10-27
- CAS:1417630-95-5
- Min. Order:
- Purity:
- Supply Ability: 10g
- PIM1-IN-1
-
- $2360.00 / 100mg
-
2025-08-22
- CAS:1417630-95-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | PIM1-IN-1 Basic information |
| Product Name: | PIM1-IN-1 | | Synonyms: | PIM1-IN-1;PIM1 IN 1,PIM1IN1,PIM-1-IN-1;8-Quinolinamine, 2-[8,9-dihydro-7-(2-methoxyethyl)-7H-1,2,4-triazolo[4',3':2,3]pyridazino[4,5-b][1,4]oxazin-3-yl]-N-(4-piperidinylmethyl)- | | CAS: | 1417630-95-5 | | MF: | C25H30N8O2 | | MW: | 474.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1417630-95-5.mol |  |
| | PIM1-IN-1 Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 45 mg/mL (94.82 mM; Need ultrasonic) | | pka | 10.48±0.10(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | PIM1-IN-1 Usage And Synthesis |
| Uses | PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1]. | | Biological Activity | PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1].
PIM1-IN-1 (Compound 42) exhibits antiproliferative activity, with GI50 of 1.48 μM for melanoma cell line SKMEL-19. PIM1-IN-1 has significant synergistic effect combined with different antitumoral agents in different tumor cell lines[1]. PIM1-IN-1 (2.5, 5, or 10 μM, 24 hours) induces apoptosis in SKMEL19 cells[1].
PIM1-IN-1 shows cceptable clearance of 1.26 L/h/kg in BALB-C mice[1]. | | in vivo | PIM1-IN-1 shows cceptable clearance of 1.26 L/h/kg in BALB-C mice[1]. | | IC 50 | PIM1: 7 nM (IC50); PIM3: 70 nM (IC50); PIM2: 5530 nM (IC50) | | References | [1]. Martínez-González S, et al. Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors. Eur J Med Chem. 2019 Feb 19;168:87-109. |
| | PIM1-IN-1 Preparation Products And Raw materials |
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