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| | Histone H3K27Me3 (21-44)-K-biotin (trifluoroacetate salt) Basic information |
| | Histone H3K27Me3 (21-44)-K-biotin (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Histone H3K27Me3 (21-44)-K-biotin (trifluoroacetate salt) Usage And Synthesis |
| Description | Histone H3K27Me3 (21-44)-K-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences. It is trimethylated at lysine 27 and biotinylated via a C-terminal lysine linker. Trimethylation of histone H3 at lysine 27 is associated with gene silencing.1 It is involved in tumor progression through its regulation by enhancer of zeste homolog 2 (EZH2) and transcriptional repression of tumor suppressor genes.2,3 Levels of H3K27Me3 are reduced in 293 T-REx cells containing EEDR236T and SUZ12G610V mutations and in lymphoblastoid cells isolated from patients with Weaver syndrome, a rare overgrowth disorder characterized by EZH2, EED, or SUZ12 mutations, cancer susceptibility, and various distinctive physical features.4WARNING This product is not for human or veterinary use. | | References | [1] JUSTIN S. BECKER K Z Dario Nicetto. H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes.[J]. Trends in Genetics, 2016, 24 1: 29-41. DOI: 10.1016/j.tig.2015.11.001
[2] Z WU. Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage[J]. Cell Death and Differentiation, 2011, 18 11: 1771-1779. DOI: 10.1038/cdd.2011.48
[3] LU GAN. Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential.[J]. Biomarker Research, 2018, 6: 10. DOI: 10.1186/s40364-018-0122-2
[4] ERI IMAGAWA. Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome[J]. Human Mutation, 2017, 38 6: 637-648. DOI: 10.1002/humu.23200 |
| | Histone H3K27Me3 (21-44)-K-biotin (trifluoroacetate salt) Preparation Products And Raw materials |
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