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Product Name:Terpendole I
CAS:167612-17-1
Purity:>95% by HPLC Remarks:0
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Product Name:Terpendole I
CAS:167612-17-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Product Name:Terpendole I
CAS:167612-17-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Products Intro: |
Product Name:Terpendole I
CAS:167612-17-1
Purity:95% Package:1mg;5mg
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| | Terpendole I Basic information |
| Product Name: | Terpendole I | | Synonyms: | Terpendole I;2H,4bH-Oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b-diol, 3,3a,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2S,3R,3aR,4aS,4bS,6aS,12bS,12cR,14aS)-;(2S,3R,3aR,4aS,4bS,6aS,12bS,12cR,14aS)-3,3a,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H,4bH-oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b-diol | | CAS: | 167612-17-1 | | MF: | C27H35NO5 | | MW: | 453.57 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Terpendole I Structure]() |
| | Terpendole I Chemical Properties |
| Boiling point | 668.4±55.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid | | pka | 13.38±0.70(Predicted) |
| | Terpendole I Usage And Synthesis |
| Description | Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 | | Definition | ChEBI: Terpendole I is an organooxygen compound and an organic heterotricyclic compound. | | References | 1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components J. Antibiot. (Tokyo) 48(8),793-804(1995).
2. Zhao, J.-C., Wang, Y.-L., Zhang, T.-Y., et al. Indole diterpenoids from the endophytic fungus Drechmeria sp. as natural antimicrobial agents Phytochemistry 148,21-28(2018).
3. Nagumo, Y., Motoyama, T., Hayashi, T., et al. Structure-activity relationships of terpendole E and its natural derivatives ChemistrySelect 2(4),1533-1536(2017). |
| | Terpendole I Preparation Products And Raw materials |
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