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ChemicalBook Optimization Suppliers |
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| | N,N‐ジメチル‐D6‐ジグアニド塩酸塩 製品概要 |
| | N,N‐ジメチル‐D6‐ジグアニド塩酸塩 物理性質 |
| 融点 | 215-218°C | | 貯蔵温度 | -20°C Freezer | | 溶解性 | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly) | | 外見 | Solid | | 色 | White to Off-White | | InChI | InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H/i1D3;/hD3 | | InChIKey | OETHQSJEHLVLGH-MIOFBDNISA-N | | SMILES | N([2H])([2H])C(=N)N([2H])C(=N)N(C)C([2H])([2H])[2H].[H]Cl |
| | N,N‐ジメチル‐D6‐ジグアニド塩酸塩 Usage And Synthesis |
| 説明 | Metformin-d6 is intended for use as an internal standard for the quantification of metformin by GC- or LC-MS. Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes. | | 化学的特性 | White Crystalline Solid | | 使用 | An oral hypoglycemic agent. | | IC 50 | AMPK |
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