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| | 4-メチル-N1-(3-フェニルプロピル)-1,2-フェニレンジアミン 製品概要 |
| 化学名: | 4-メチル-N1-(3-フェニルプロピル)-1,2-フェニレンジアミン | | 英語化学名: | 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE | | 别名: | 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;JSH-23;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine JSH 23;JSH 23 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine;NFκB Activation Inhibitor II, JSH-23;JSH-23;JSH23;JSH 23;NF-ΚB ACTIVATION INHIBITOR II | | CAS番号: | 749886-87-1 | | 分子式: | C16H20N2 | | 分子量: | 240.34 | | EINECS: | | | カテゴリ情報: | Chemical Amines;Amines;Aromatics;Inhibitors | | Mol File: | Mol File |  |
| | 4-メチル-N1-(3-フェニルプロピル)-1,2-フェニレンジアミン 物理性質 |
| 融点 | 104.4-105.0℃ | | 沸点 | 418.7±40.0 °C(Predicted) | | 比重(密度) | 1.086±0.06 g/cm3(Predicted) | | 貯蔵温度 | -20°C | | 溶解性 | DMSO: >10mg/mL | | 酸解離定数(Pka) | 5.99±0.11(Predicted) | | 外見 | solid | | 色 | off-white to gray-pink |
| | 4-メチル-N1-(3-フェニルプロピル)-1,2-フェニレンジアミン Usage And Synthesis |
| 外観 | 白色～うすい黄色～うすい黄赤色粉末～結晶 | | 使用 | JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II. | | 使用 | A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23 | | 使用 | JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor. | | 定義 | ChEBI: JSH-23 is a diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. It has a role as a NF-kappaB inhibitor. It is a diamine and a substituted aniline. It is functionally related to a 1,2-phenylenediamine. | | 一般的な説明 | A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation. | | 生物活性 | jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1]. | | Biochem/physiol Actions | Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity | | target | NF-κB | | 参考文献 | [1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4. |
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