| | SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Basic information |
| Product Name: | SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE | | Synonyms: | [1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl-butyl]-dimethyl-amine hydrate hydrochloride;1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine hydrate hydrochloride;1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrate hydrochloride;1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate;Sibutramine Hydrochloride CIV (125 mg);)-SibutraMine-d6 HCl H2O;1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride;CyclobutaneMethanaMine,1-(4-chlorophenyl)-N,N-diMethyl-a-(2-Methylpropyl)-, hydrochloride, hydrate (1:1:1) | | CAS: | 125494-59-9 | | MF: | C17H29Cl2NO | | MW: | 334.32 | | EINECS: | 603-075-3 | | Product Categories: | CRESTOR;Intermediates & Fine Chemicals;Pharmaceuticals;Anilines, Aromatic Amines and Nitro Compounds | | Mol File: | 125494-59-9.mol |  |
| | SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Chemical Properties |
| Melting point | 193-195.5°C | | Fp | 9℃ | | storage temp. | Room temp | | solubility | DMSO: >30mg/mL | | form | solid | | color | white |
| | SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Usage And Synthesis |
| Description | Sibutramine was introduced as Meridia in the US for the control of
obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared
in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and
noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by
creating a satieted feeling and increases energy expenditure by enhancing
thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of
Sibutramine once-daily, meaningful weight loss was sustained for 12 months ;
an additional study demonstrated a lack of abuse potential. An appreciable part
of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites,
which are very potent monoamine reuptake inhibitors
themselves. | | Chemical Properties | White Solid | | Originator | Knoll (Germany) | | Uses | A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure | | Uses | antihyperlipidemic | | Uses | antiobesity agent;neurotransmitter reuptake inhibitor | | Brand name | Meridia (Abbott);Meridia, Reductil. |
| | SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Preparation Products And Raw materials |
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