|
ChemicalBook Optimization Suppliers |
|
| 融点 | 204-206°C | | 貯蔵温度 | -20°C | | 溶解性 | DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)
PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM) | | 外見 | powder | | 色 | white to beige | | CAS データベース | 88475-69-8(CAS DataBase Reference) |
| | ベラプロストナトリウム Usage And Synthesis |
| 効能 | 血圧降下薬, 血小板凝集抑制薬, プロスタグランジンI2受容体作動薬 | | 商品名 | ケアロード (東レ); ドルナー (東レ); プロサイリン (科研製薬); ベラサス (科研製薬) | | 説明 | Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and
Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP
in platelets which is achieved by activating adenylate cyclase in the platelet membrane,
followed by the inhibition ofCa++- influx and thromboxane A2 formation. | | 説明 | Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 μg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension. Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses. | | 化学的特性 | White Solid | | Originator | Toray (Japan) | | 使用 | Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral). | | 定義 | ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-). | | brand name | Dorner; Dorner;Procylin | | 一般的な説明 | Beraprost sodium is an orally active prostacyclin analog. | | Biochem/physiol Actions | Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation. |
|