氯德拉苯
| 中文名称 | 氯德拉苯 |
|---|---|
| 中文同义词 | 氯德拉苯;化合物 T11865;LODELABEN (SC-39026) |
| 英文名称 | Declaben |
| 英文同义词 | Declaben;Lodelaben;Benzoic acid, 2-chloro-4-(1-hydroxyoctadecyl)-;Lodelabenum;Lodelabenum [inn-latin];SC-39026;Lodelaben (SC-39026) |
| CAS号 | 111149-90-7 |
| 分子式 | C25H41ClO3 |
| 分子量 | 425.04 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 111149-90-7.mol |
| 结构式 |  |
氯德拉苯 性质
| 沸点 | 539.8±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.038±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3.09±0.25(Predicted) |
IC50: 0.5 μM (elastase) Ki: 1.5 μM (elastase)
Lodelaben is a human neutrophil elastase inhibitor with an IC 50 and K i of 0.5 and 1.5 μM, respectively. Results indicate that the inhibition of human neutrophil elastase (HNE) by Lodelaben is non-competetive. Lodelaben is not inhibitory at 10 μM with the synthetic substrates or at 5 μM vith Azocoll. Pseudomonas aeruginosa elastase, a metallo-protease is not inhibited by Lodelaben. Cathepsin G activity, however, is inhibited by Lodelaben, with an IC 50 of approximately 2.5 μM, with Azocoll as substrate.
The mean pulmonary artery pressures of the saline/vehicle and saline/Lodelaben groups are similar, 16.4±1.1 and 17.4±0.9 mm Hg, respectively. Although, mean pulmonary artery pressure in the monocrotaline/vehicle group is 27.5±0.8 mm Hg, treatment of monocrotaline rats with Lodelaben results in significantly lower values (21.00±1.6 mm Hg, p<0.05). Saline/vehicle and saline/Lodelaben rats have only a small percentage of arteries muscularized at the alveolar wall level (1.9±1.4 and 0.4±0.4%, respectively). Treatment of monocrotaline-injected rats with Lodelaben results in a decreased percentage of alveolar wall arteries muscularized (10.0±3.6%).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100240 | Lodelaben | 1 mg | 9800元 | |
| 2023/03/20 | HY-100240 | 氯德拉苯 Lodelaben | 111149-90-7 | 5mg | 36000元 |