(2R,3R,4R)-2-羟甲基哌啶-3,4-二醇
| 中文名称 | (2R,3R,4R)-2-羟甲基哌啶-3,4-二醇 |
|---|---|
| 中文同义词 | 荞麦碱;桑叶生物碱;(2R,3R,4R)-2-羟甲基哌啶-3,4-二醇;荞麦碱, >98%;乔麦碱;FAGOMINE,荞麦碱;法古米 |
| 英文名称 | fagomine |
| 英文同义词 | fagomine;(2R)-2-(Hydroxymethyl)piperidine-3β,4α-diol;(2R)-2α-(Hydroxymethyl)piperidine-3β,4α-diol;(2R)-3β,4α-Dihydroxypiperidine-2α-methanol;1,2,5-Trideoxy-1,5-epimino-D-xylo-hexitol;(2R,3R,4R)-3,4-Dihydroxy-2-piperidinemethanol;(2R,3R,4R)-2-(Hydroxymethyl)piperidine-3,4-diol;D-FagoMine |
| CAS号 | 53185-12-9 |
| 分子式 | C6H13NO3 |
| 分子量 | 147.17 |
| EINECS号 | |
| 相关类别 | 植物提取物;对照品;标准品 -中药标准品 |
| Mol文件 | 53185-12-9.mol |
| 结构式 |  |
(2R,3R,4R)-2-羟甲基哌啶-3,4-二醇 性质
| 熔点 | 185-186℃ |
|---|---|
| 沸点 | 315.4±42.0 °C(Predicted) |
| 密度 | 1.279 |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.16±0.60(Predicted) |
| 颜色 | 白色至卡其色 |
| LogP | -0.880 (est) |
Glycosidase
Fagomine (D-fagomine) is an iminosugar that has been shown to selectively agglutinate Enterobacteriales in vitro. Fagomine selectively agglutinates fimbriated enterobacteria (e.g., E.coli ) and inhibits their adhesion to the intestinal mucosa; the reason for this is probably related to its structural similarity with lectin-binding saccharides (e.g., mannose). Fagomine is capable of altering this effect of high-fat high-sucrose diet (HFHS) on the proportion of Enterobacteriales and E.coli .
Fagomine (D-fagomine) is a natural iminosugar that counteracts the short-term effects of a high-energy-dense diet on body weight, fasting blood glucose levels and the proportion of gut Enterobacteriales. Compare to the standard group, rats fed high-fat high-sucrose diet (HFHS) with Fagomine (D-fagomine) gain significantly less weight (15.3%) than those fed HFHS (20.9%).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-13005 | (2R,3R,4R)-2-羟甲基哌啶-3,4-二醇 Fagomine | 53185-12-9 | 1 mg | 2045元 |
| 2025/05/22 | HY-13005 | (2R,3R,4R)-2-羟甲基哌啶-3,4-二醇 Fagomine | 53185-12-9 | 5mg | 4500元 |