| Company Name: |
Zhejiang Huida Biotech Co., LTD
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| Tel: |
0571-89903882 18679456698 |
| Email: |
mingxinzhu@huidabiotech.com |
| Products Intro: |
Product Name:Holomycin
CAS:488-04-0
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Holomycin
CAS:488-04-0
Purity:NULL Package:2.5mg;25mg Remarks:NULL
|
holomycin manufacturers
- Holomycin
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- $298.00 / 1mg
-
2025-12-10
- CAS:488-04-0
- Min. Order:
- Purity: 98.76%
- Supply Ability: 10g
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| | holomycin Basic information |
| Product Name: | holomycin | | Synonyms: | holomycin;N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;N-Demethylthiolutin;N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide;Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-;Holomycin, 10 mM in DMSO | | CAS: | 488-04-0 | | MF: | C7H6N2O2S2 | | MW: | 214.26 | | EINECS: | | | Product Categories: | | | Mol File: | 488-04-0.mol |  |
| | holomycin Chemical Properties |
| Melting point | 268 °C (decomp) | | Boiling point | 532.1±50.0 °C(Predicted) | | density | 1.63±0.1 g/cm3(Predicted) | | solubility | DMSO, Methanol (Heated) | | form | Solid | | pka | 9.33±0.40(Predicted) | | color | Brown-Orange |
| Toxicity | LD50 i.v. in mice: 5-10 mg/kg (Von Daehne) |
| | holomycin Usage And Synthesis |
| Uses | Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity. | | Definition | ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides. | | Synthesis Reference(s) | Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049 |
| | holomycin Preparation Products And Raw materials |
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