海恩酮
中文名称 | 海恩酮 |
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中文同义词 | 海恩酮;羟甲硫蒽酮;1-((2-(二乙基氨基)乙基)氨基)-4-(羟甲基)-9H-噻吨-9-酮 |
英文名称 | Hycanthone |
英文同义词 | 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE;ETRENOL;Etrenol(mesylate);Win 249-33;1-(2-diethylaminoethylamino)-4-methylol-thioxanthen-9-one;9H-Thioxanthen-9-one, 1-[[2-(diethylaMino)ethyl]aMino]-4-(hydroxyMethyl)-;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-9h-thioxanthen-9-on;1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one |
CAS号 | 3105-97-3 |
分子式 | C20H24N2O2S |
分子量 | 356.48 |
EINECS号 | 221-463-7 |
相关类别 | 有机化工原料 |
Mol文件 | 3105-97-3.mol |
结构式 |
海恩酮 性质
熔点 | 100.6-102.8° |
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沸点 | 570.5±50.0 °C(Predicted) |
密度 | 1.1269 (rough estimate) |
折射率 | 1.6000 (estimate) |
储存条件 | Keep in dark place,Sealed in dry,2-8°C |
溶解度 | 二甲基亚砜:30 mg/mL(84.16 mM) |
酸度系数(pKa) | pKa 3.40 (Uncertain) |
EPA化学物质信息 | Hycanthone (3105-97-3) |
Topoisomerase I
|
Topoisomerase II
|
Hycanthone has an IC
50
of 80 nM for inhibition of APE1 incision of depurinated plasmid DNA.
Hycanthone (0.05-100 µM; for 2 h) promotes APE1 cleavage in presence of Cycloheximide (CHX) and this cleavage is inhibited by 1% DMSO.
Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Results reveal that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively reduces viral interferon yields as much as 73% compare to that of controls.
Results show that the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease after treatment with Hycanthone. Immature worms are totally unaffected by Hycanthone at all times tested. Male worms treated with Hycanthone show signs of a possible partial recovery from the initial low levels of incorporation. The incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50% in the first four days after treatment. Results show that, 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules.
[2] 张继瑜, 邱燕华, 翟斌涛, et al. 海恩酮在制备治疗弓形虫感染疾病药物中的应用.
[3] D. CLIVE M. R M W G Flamm. Mutagenicity of hycanthone in mammalian cells[J]. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1972, 14 2: Pages 262-264. DOI:10.1016/0027-5107(72)90055-3.
[4] PHILIP E. HARTMAN. Hycanthone: A Frameshift Mutagen[J]. Science, 1971, 172 3987. DOI:10.1126/science.172.3987.1058.
安全信息
危险品标志 | T |
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危险类别码 | 45-46-20/21/22 |
安全说明 | 53-36/37/39-45 |
WGK Germany | 3 |
RTECS号 | XO1590000 |
提供商 | 语言 |
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英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-B1099 | Hycanthone | 5 mg | 312元 | |
2024/01/25 | HY-B1099 | 海恩酮 Hycanthone | 3105-97-3 | 10mg | 500元 |