1-氨基苯并三唑
中文名称 | 1-氨基苯并三唑 |
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中文同义词 | 1-氨基苯并三唑;1-氨基苯并三氮唑;1-苯并三唑胺;1H-苯并[D][1,2,3]三唑-1-胺;1-氨基苯并三唑, 用于合成;2-氨基苯并三氮唑;1H-苯并三唑-1-胺;D-(+)-核糖酸-1 |
英文名称 | 1-Aminobenzotriazole |
英文同义词 | 1-Benzotriazolylamine;1-Benzotriazolamine, ABT;1-(Thiophen-2-yl)-4-[(2-aminoethyl)amino]-1-butanone;4-[(2-Aminoethyl)amino]-1-(2-thienyl)butan-1-one;1-Amino-1H-benzotriazole;1-Aminobenzotriazole,98%;1-Aminobenzotriazole,99+%;1-Amino-1H-benzotriazole 97% |
CAS号 | 1614-12-6 |
分子式 | C6H6N4 |
分子量 | 134.14 |
EINECS号 | |
相关类别 | 三唑;胺类;对照品;Fused Ring Systems;inhibitor;Miscellaneous;Amines;API intermediates |
Mol文件 | 1614-12-6.mol |
结构式 |
1-氨基苯并三唑 性质
熔点 | 81-84 °C (lit.) |
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沸点 | 237.24°C (rough estimate) |
密度 | 1.2769 (rough estimate) |
折射率 | 1.7000 (estimate) |
RTECS号 | DM1235000 |
储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
溶解度 | 可溶于DMSO(高达30mg/ml) |
形态 | 结晶粉末 |
酸度系数(pKa) | 2.09±0.30(Predicted) |
颜色 | 黄色至米色或浅棕色 |
水溶解性 | slightly soluble |
BRN | 607843 |
稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
CAS 数据库 | 1614-12-6(CAS DataBase Reference) |
Target | Value |
P450
() | |
NAT
() |
1-Aminobenzotriazole (ABT) alone significantly increases the expression levels of CYP2B6 in two different hepatocytes (7.3- and 10.8-fold, respectively). Upon co-treatment with 1-Aminobenzotriazole, the induction of CYP2B6 expression by CITCO or rifampin is potentiated: 12.6- and 4.0-fold for CITCO as well as 3.9- and 2.5-fold for rifampin. 1-Aminobenzotriazole has a greater potentiation effect on CITCO than on rifampin. 1-Aminobenzotriazole alone increases the expression levels of CYP3A4 in tow different hepatocytes (by 2.0- and 3.8-fold). Upon co-treatment with 1-Aminobenzotriazole, the effects of CITCO on CYP3A4 expression levels are potentiated by 3.8- and 6.0- fold as compare to cells treated with CITCO alone. 1-Aminobenzotriazole (ABT) (1 mM) shows pronounced (~95%) inhibition of the formation of N-acetylprocainamide compare with the control without 1-Aminobenzotriazole.
Oral 1-Aminobenzotriazole (ABT) (100 mg/kg, 2 h predose) decreases the clearance of intravenous procainamide (45%) in rats, accompanied by a decreased N-acetylprocainamide-to-procainamide ratio in urine (0.74 versus 0.21) and plasma (area under the curve ratio 0.59 versus 0.11). The urinary recovery of procainamide increases from 18 to 30%, whereas the recovery of N-acetylprocainamide in urine decreases from 13.3 to 6.5% with 1-Aminobenzotriazole. Pretreatment of rats with 100 mg/kg oral 1-Aminobenzotriazole (ABT) administered 2 hours before a semisolid caloric test meal markedly delays gastric emptying. 1-Aminobenzotriazole also increases stomach weights by 2-fold.
安全信息
危险品标志 | Xi |
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危险类别码 | 36/37/38 |
安全说明 | 26-36-37/39 |
WGK Germany | 3 |
Hazard Note | Irritant |
海关编码 | 29349990 |
提供商 | 语言 |
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英文
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英文
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