GAP26
中文名称 | GAP26 |
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中文同义词 | VR-13;化合物GAP 26;GAP 26游离态;H-VAL-CYS-TYR-ASP-LYS-SER-PHE-PRO-ILE-SER-HIS-VAL-ARG-OH;穿膜肽GAP 26;间隙连接的阻断肽:GAP26;GAP26 TRIFLUOROACETATE |
英文名称 | GAP 26 |
英文同义词 | GAP 26;M.W. 1550.78 C70H107N19O19S;Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg;43Gap 26, Connexin Mimetic;GAP-26; GAP26;L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-;GAP 26/Connexin 43 (63-75) (human, bovine, mouse, rat), Gap Junction α-1 Protein (63-75);Gap26 trifluoroacetate |
CAS号 | 197250-15-0 |
分子式 | C70H107N19O19S |
分子量 | 1550.78 |
EINECS号 | |
相关类别 | 目录肽;目录多肽;CancerBiology;Various Peptides |
Mol文件 | 197250-15-0.mol |
结构式 |
GAP26 性质
密度 | 1.47±0.1 g/cm3(Predicted) |
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储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | 不溶于乙醇;超声检测水中≥155.1 mg/mL; DMSO 中≥77.55 mg/mL,温和加热和超声波 |
形态 | 固体 |
酸度系数(pKa) | 3.31±0.10(Predicted) |
颜色 | 白色至米白色 |
水溶解性 | Soluble to 2 mg/ml in water |
序列 | H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH |
Target | Value |
gap junction
() |
Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected.
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used.
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC
50
of 28.4 ± 3.4 μM.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
海关编码 | 2922498590 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 1mg | 900元 |
2024/08/19 | HY-P1082 | GAP26 Gap 26 | 197250-15-0 | 5mg | 1800元 |