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| | 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 製品概要 |
| 化学名: | | | 英語化学名: | 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- | | 别名: | 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-;SC75741;V 1810;N-(6-Benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide;75741;CS-2697;4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- USP/EP/BP | | CAS番号: | 913822-46-5 | | 分子式: | C29H23N7O2S2 | | 分子量: | 565.67 | | EINECS: | | | カテゴリ情報: | Inhibitors | | Mol File: | 913822-46-5.mol | ![4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)-](CAS/GIF/913822-46-5.gif) |
| | 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 物理性質 |
| 比重(密度) | 1.483±0.06 g/cm3(Predicted) | | 貯蔵温度 | 2-8°C | | 溶解性 | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | | 外見 | powder | | 酸解離定数(Pka) | 9.11±0.10(Predicted) | | 色 | white to beige |
| | 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- Usage And Synthesis |
| 説明 | SC-75741 is an inhibitor of NF-κB (EC50 = 0.1 μM in an NF-κB reporter gene assay). It inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner. It also reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells. In vivo, SC-75741 (15 mg/kg, i.p.) reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice. SC-75741 is also protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection. | | 使用 | SC75741 is a potent NF-κB inhibitor with EC50. | | target | NF-κB |
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