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| | Fatostatin A Basic information |
| Product Name: | Fatostatin A | | Synonyms: | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;125B11;Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-;2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole;mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated | | CAS: | 125256-00-0 | | MF: | C18H18N2S | | MW: | 294.41 | | EINECS: | | | Product Categories: | | | Mol File: | 125256-00-0.mol |  |
| | Fatostatin A Chemical Properties |
| Boiling point | 474.3±55.0 °C(Predicted) | | density | 1.125±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO (up to 25 mg/ml). | | form | solid | | pka | 3.46±0.10(Predicted) | | color | Yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | Fatostatin A Usage And Synthesis |
| Description | Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable. | | Uses | Fatostatin A is Cell permeable inhibitor of SREBP activation. | | Definition | ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles. | | References | 1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882
2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329 |
| | Fatostatin A Preparation Products And Raw materials |
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