XL-647

XL-647 Suppliers list
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:XL-647
CAS:781613-23-8
Purity:99% Package:3KG;3USD
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:XL-647
CAS:781613-23-8
Purity:>98% Package:5 mg Remarks:Reach out to us for more information about custom solutions.
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:XL647
CAS:781613-23-8
Purity:99% Package:5KG;1KG Remarks:XL647
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:Tesevatinib
CAS:781613-23-8
Purity:97.89% Package:1mg;65USD|5mg;148USD|10mg;289USD
Company Name: Aceschem Inc.
Tel: +1-817863-6948 +1-(817)863-6948
Email: sales@aceschem.com
Products Intro: Product Name:Tesevatinib
CAS:781613-23-8
Purity:NLT98% Package:1G;100G;1KG;50KG;100KG Remarks:ACF021380

XL-647 manufacturers

  • Tesevatinib
  • Tesevatinib pictures
  • $109.00 / 1mg
  • 2025-07-15
  • CAS:781613-23-8
  • Min. Order:
  • Purity: 97.89%
  • Supply Ability: 10g
  • XL-647
  • XL-647 pictures
  • $3.00 / 3KG
  • 2019-08-08
  • CAS:781613-23-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100kg
XL-647 Basic information
Product Name:XL-647
Synonyms:Tesevatinib;Tesevatinib(XL647);XL-647;N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine;N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine;EXEL-7647;XL-647;XL 647;KD-019;Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
CAS:781613-23-8
MF:C24H25Cl2FN4O2
MW:491.3853032
EINECS:
Product Categories:
Mol File:781613-23-8.mol
XL-647 Structure
XL-647 Chemical Properties
Boiling point 567.9±50.0 °C(Predicted)
density 1.356
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form A solid
pka10.16±0.40(Predicted)
color White to off-white
InChIKeyHVXKQKFEHMGHSL-QKDCVEJENA-N
SMILESN(C1C=CC(Cl)=C(Cl)C=1F)C1=NC=NC2C=C(OC[C@H]3C[C@@]4([H])CN(C)C[C@@]4([H])C3)C(OC)=CC1=2 |&1:19,21,27,r|
Safety Information
MSDS Information
XL-647 Usage And Synthesis
UsesXL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.
DefinitionChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.
in vivo

Tesevatinib (XL-647) shows potent and long-lived inhibition of the WT EGFRin vivo. Tesevatinib (XL-647) substantially inhibits the growth of H1975 xenograft tumors and reduces both tumor EGFR signaling and tumor vessel density[1].

IC 50EGFR: 0.3 nM (IC50); ErbB2: 16 nM (IC50); KDR: 1.5 nM (IC50); Flt-4: 8.7 nM (IC50)
XL-647 Preparation Products And Raw materials
Tag:XL-647(781613-23-8) Related Product Information
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