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Y16

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Y16 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Y16
CAS:429653-73-6
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:Y16
CAS:429653-73-6
Purity:Min98% HPLC/GC Package:1g;1USD
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Y16
CAS:429653-73-6
Purity:98% Package:10mg Remarks:V28342
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Y16
CAS:429653-73-6
Package:1 mL * 10mM (in DMSO)；10 mg；2 mg；25 mg；5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054
Email: trendseenbio@gmail.com
Products Intro: Product Name:4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
CAS:429653-73-6
Purity:99% Package:1kg；25kg
Y16 Basic information
Product Name:Y16
Synonyms:Y16;4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione;Y16, 429653-73-6;Y16, >98%;3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-;Inhibitor,inhibit,Y-16,Y 16,Ras,Y16;4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione
CAS:429653-73-6
MF:C24H20N2O3
MW:384.43
EINECS:
Product Categories:
Mol File:429653-73-6.mol
Y16 Structure
Y16 Chemical Properties
density 1.273±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka8.84±0.20(Predicted)
form powder
color , faint yellow to dark orange
Safety Information
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
MSDS Information
Y16 Usage And Synthesis
Biological ActivityY16 is an inhibitor of G protein-coupled Rho GEFs. It blocks the binding of LARG and Rho with a Kd of 80 nM.
in vitro

Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours ; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.

Cell Viability Assay

Cell Line: NIH 3T3 cells
Concentration: 10 μΜ, 30 μΜ
Incubation Time: 24 hours
Result: Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA.

Western Blot Analysis

Cell Line: NIH 3T3 cells
Concentration: 10 μΜ, 30 μΜ
Incubation Time: 24 hours
Result: Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.
target
TargetValue
RhoGEFs
()
Y16 Preparation Products And Raw materials
Tag:Y16(429653-73-6) Related Product Information
1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Y 11 TENOVIN-1 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 CNX-1351 Mutant IDH1 inhibitor