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4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine

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4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:VPC-14449；VPC 14449;VPC14449
CAS:1621375-32-3
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:VPC 14449
CAS:1621375-32-3
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: ChemShuttle, Inc.  
Tel: 0510-83588313-802 18800520310;
Email: sales@chemshuttle.com
Products Intro: Product Name:4-(4-(2,4-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine
CAS:1621375-32-3
Purity:95% Package:5mg;25mg;100mg;500mg;1g;5g;10g;25g;50g;100g;250g;500g;kg…
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:VPC-14449
CAS:1621375-32-3
Purity:98% Package:5mg;10mg;25mg
Company Name: Wuxi KaideRui Pharmaceutical Technology Co., Ltd  
Tel: 19906241957
Email: 1557216087@qq.com
Products Intro: CAS:1621375-32-3
Purity:98% HPLC Package:1 g; 5 g; 10 g; 25 g; 100 g;
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Basic information
Product Name:4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine
Synonyms:4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine;187295;4-(4-(2,4-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine;Morpholine, 4-[4-(2,4-dibromo-1H-imidazol-1-yl)-2-thiazolyl]-
CAS:1621375-32-3
MF:C10H10Br2N4OS
MW:394.09
EINECS:
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Mol File:1621375-32-3.mol
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Structure
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Chemical Properties
Boiling point 551.4±60.0 °C(Predicted)
density 2.12±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (317.19 mM; Need ultrasonic)
pka2.01±0.50(Predicted)
Safety Information
MSDS Information
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Usage And Synthesis
Biological ActivityVPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD), with IC50 of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer[1][2]. VPC-14449 (0.01-100 μM; 24 h) inhibits AR-transcriptional activity and cell viability in LNCaP, C4-2, MR49F, and 22Rv1 cells[2].VPC-14449 (0.01-100 μM; 24 h) dose-dependently inhibits the transiently expressed full-length human AR in PC3 cells (IC50=0.34 μM) without affecting AR protein expression[1]. VPC-14449 (100 mg/kg; i.p. twice daily for 4 weeks) reduces tumor volume and abolishes PSA production with no decrease in body weight over a total duration 4 weeks in LNCaP xenograft model[1].
References[1]. Dalal K, et, al. Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. J Biol Chem. 2014 Sep 19;289(38):26417-26429. [2]. Dalal K, et, al. Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions. Mol Cancer Ther. 2017 Oct;16(10):2281-2291.
4-(4-(4,5-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine Preparation Products And Raw materials
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