| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:KC02
CAS:1646795-60-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:(Z)-KC02
CAS:1646795-60-9
Package:1mg/RMB 5230
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:KC02
CAS:1646795-60-9
Purity:98% Package:100μg;500μg;1mg
|
| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:KC02
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| Company Name: |
Neobioscience Co., Ltd.
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| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:KC02
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| Product Name: | KC02 | | Synonyms: | KC02;Hexanamide, 6-[2-oxo-4-(2-phenylethyl)-3-oxetanylidene]-, (6Z)-;6Z-[2-oxo-4-(2-phenylethyl)-3-oxetanylidene],hexanamide;(Z)-KC02 | | CAS: | 1646795-60-9 | | MF: | C17H21NO3 | | MW: | 287.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1646795-60-9.mol |  |
| Boiling point | 563.2±33.0 °C(Predicted) | | density | 1.193±0.06 g/cm3(Predicted) | | solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 16 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.5 mg/ml | | pka | 16.55±0.40(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| Description | KC02 is an inactive control probe for KC01 , the potent inhibitor of ABHD16A, a phosphatidylserine hydrolase that regulates the formation of lysophosphatidylserines in mammalian systems. KC02 demonstrates IC50 values greater 10 μM against human and mouse ABHD16A. | | Uses | (Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo[1]. | | References | [1] Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol. 2015 Feb;11(2):164-71. DOI:10.1038/nchembio.1721 |
| | KC02 Preparation Products And Raw materials |
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