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| 融点 | 67-71 °C | | 沸点 | 238.5℃[at 101 325 Pa] | | 比重(密度) | 0.75 | | 蒸気圧 | 5.333Pa at 25℃ | | 屈折率 | 1.6100 (estimate) | | 貯蔵温度 | 2-8°C | | 溶解性 | H2O: 1 m at 20 °C, clear, colorless | | 外見 | Crystalline Powder or Pellets | | 色 | White | | PH | 3.3-5.0 (400g/l, H2O, 20℃) | | 水溶解度 | VERY SOLUBLE | | Sensitive | Hygroscopic | | 極大吸収波長 (λmax) | λ: 280 nm Amax: ≤0.3 | | Merck | 14,2779 | | BRN | 3590083 | | 安定性： | Stable, but hygroscopic. Incompatible with strong oxidizing agents. | | InChIKey | OGMADIBCHLQMIP-UHFFFAOYSA-N | | LogP | -2.14 at 25℃ | | CAS データベース | 156-57-0(CAS DataBase Reference) | | EPAの化学物質情報 | Cysteamine hydrochloride (156-57-0) |
| | 2-アミノエタンチオール塩酸塩 Usage And Synthesis |
| 外観 | 白色～わずかにうすい褐色、結晶又は粒状 | | 定義 | 本品は、次の化学式で表されるアミンの塩酸塩である。 | | 溶解性 | 水及びエタノールに溶ける。 | | 化粧品の成分用途 | パーマネント.ウェーブ用還元剤、還元剤 | | 効能 | 尿路結石治療薬 (システイン結石), シスチン症治療薬 | | 使用上の注意 | アルゴン封入 | | 説明 | Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans. | | 化学的特性 | White Solid | | 使用 | Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd2+ and S2-. | | 使用 | Cysteamine hydrochloride is used as an antioxidant and in radiation therapy. | | 使用 | An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors. | | 一般的な説明 | Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. | | 危険性 | Toxic by inhalation and ingestion. | | Biochem/physiol Actions | Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles. | | 合成 |
In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.
| | 純化方法 | Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.] |
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