| Company Name: |
Taizhou Tongxin Bio-Tech Co., Ltd
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| Tel: |
0523-18601685-898 18652728585 |
| Email: |
sales@allyrise.com |
| Products Intro: |
Product Name:4-((tert-Butoxycarbonyl)amino)butyl 4-methylbenzenesulfonate
CAS:180851-50-7
Purity:98% Package:1g;10g;100g
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:Tos-O-C4-NH-Boc
CAS:180851-50-7
Purity:98% HPLC Package:100mg，250mg，1g
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| | Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester Basic information |
| Product Name: | Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester | | Synonyms: | Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester;Toluene-4-sulfonic acid 4-bocamino-butyl ester, 97%;Carbamic acid, N-[4-[[(4-methylphenyl)sulfonyl]oxy]butyl]-, 1,1-dimethylethyl ester;Tos-O-C4-NH-Boc;Toluene-4-sulfonic acid 4-bocamin;4-((tert-Butoxycarbonyl)amino)butyl 4-methylbenzenesulfonate | | CAS: | 180851-50-7 | | MF: | C16H25NO5S | | MW: | 343.44 | | EINECS: | | | Product Categories: | | | Mol File: | 180851-50-7.mol |  |
| | Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester Chemical Properties |
| Melting point | 54-55 °C | | Boiling point | 491.0±28.0 °C(Predicted) | | density | 1.151±0.06 g/cm3(Predicted) | | pka | 12.75±0.46(Predicted) |
| | Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester Usage And Synthesis |
| Biological Activity | Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 [1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21. |
| | Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester Preparation Products And Raw materials |
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