| Company Name: |
GL Biochem (Shanghai) Ltd
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| Tel: |
21-61263452 13641803416 |
| Email: |
ymbetter@glbiochem.com |
| Products Intro: |
Product Name:390 MMP FRET Substrate III;Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2
Purity:95% HPLC 98% HPLC Package:1mg,5mg,10mg,25mg,100mg,1g,10g
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:MMP 2 Substrate, fluorogenic
Purity:>=95% (HPLC) Package:5MG Remarks:SCP0192-5MG
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| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
eric@peptidego.com |
| Products Intro: |
Product Name:MMP 2 Substrate, fluorogenic；390 MMP FRET Substrate III
Purity:95% or 98% Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
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| Tel: |
meitaochem@126.com |
| Email: |
meitaochem@126.com |
| Products Intro: |
Product Name:390 MMP FRET Substrate III; Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2
Purity:99% HPLC Package:500g;1kg;5kg;25kg
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| Company Name: |
Wuxi Helen Biotechnology Co., Ltd.,
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| Tel: |
0510-85629785 18013409632 |
| Email: |
sales@reading-chemicals.com |
| Products Intro: |
Product Name:MMP 2 Substrate, fluorogenic；390 MMP FRET Substrate III
Purity:>=95% Package:10mg;25mg;50mg;100mg;200mg;500mg
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| | MMP-2 SUBSTRATE, FLUOROGENIC Basic information |
| Product Name: | MMP-2 SUBSTRATE, FLUOROGENIC | | Synonyms: | MCA-PRO-LEU-ALA-NVA-DAP(DNP)-ALA-ARG-NH2;MCA-PRO-LEU-ALA-NVA-DPA-ALA-ARG-NH2;MCA-PLA-NVA-DAP(DNP)-AR-NH2;390 MMP FRET SUBSTRATE III;MMP-2 SUBSTRATE, FLUOROGENIC | | CAS: | | | MF: | C50H70N14O15 | | MW: | 1107.18 | | EINECS: | | | Product Categories: | peptide | | Mol File: | Mol File |  |
| | MMP-2 SUBSTRATE, FLUOROGENIC Chemical Properties |
| | MMP-2 SUBSTRATE, FLUOROGENIC Usage And Synthesis |
| Uses | Matrix metalloproteinases (MMP) are a family of zinc-dependent endopeptidases that degrade matrix proteins. MMPs include collagenases, gelatinases, matrilysins, enamelysins, metalloelastases, stromelysins and other structural protein and receptor lysins. The activity of these enzymes is selectively inhibited or measured by appropriately labeled peptides. MCA-Pro-Leu-Ala-Nva-DNP-Dap-Ala-Arg-NH2; DNP-Pro-Leu-Gly-Met-Trp-Ser-Arg (DNP-PLGMWSR), Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 (DNP-PLGLWA-D-R-NH2), Dnp-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH (DNP-PQGIAGQ-D-R-OH) and MOCAc [(7-methoxy coumarin-4-yl) acetyl]-RPKPYANvaWMK(Dnp[2,4-dinitrophenyl])-NH(2) are substrates for matrix metalloproteinase 2. | | General Description | Matrix metalloproteinases (MMPs) are localized to the nucleus, mitochondria, vesicles and cytoplasm. MMP family comprises of 25 members, of which 24 are present in mammals. MMPs are encoded as inactive enzymes and are localized to cell membranes. All MMP members possess pro domain (80 amino acids) and catalytic domains. | | Biochem/physiol Actions | Matrix metalloproteinases (MMPs) are responsible for degrading membrane proteins, such as basal lamina proteins of cerebral blood vessels. Proteolysis of intracellular substrates by MMPs is associated with the innate immune system and apoptosis. They are also involved in disease conditions such as oncogenesis, cardiac, neurological and autoimmune disorders. MMPs are also associated with pathogenesis related to protein conformational changes. Elevated expression of a number of MMPs is observed in myocardial infarction and heart failure. |
| | MMP-2 SUBSTRATE, FLUOROGENIC Preparation Products And Raw materials |
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