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| 融点 | 131-133 °C(lit.) | | 比旋光度 | -150 º (c=2.5, H2O) | | 沸点 | 214.6°C (rough estimate) | | 比重(密度) | 1.1677 (rough estimate) | | 屈折率 | -153.5 ° (C=1, H2O) | | 闪点 | >190℃ | | 貯蔵温度 | Store below +30°C. | | 溶解性 | 109.8g/l soluble | | 外見 | Crystalline Powder, Crystals or Flakes | | 酸解離定数(Pka) | 3.37(at 25℃) | | 色 | White to slightly yellow-beige | | PH | 3.34(1 mM solution);2.75(10 mM solution);2.22(100 mM solution); | | 光学活性 (optical activity) | [α]25/D 151°, c = 1 in ethanol | | 水溶解度 | It is partly soluble in water, freely soluble in isopropyl and ethyl alcohol. | | Sensitive | Light Sensitive | | BRN | 2691094 | | 安定性： | Stable, but light sensitive. Combustible. Incompatible with strong bases, strong oxidizing agents. | | InChIKey | IWYDHOAUDWTVEP-SSDOTTSWSA-N | | LogP | 0.550 (est) | | CAS データベース | 611-71-2(CAS DataBase Reference) | | EPAの化学物質情報 | Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)- (611-71-2) |
| | D-(-)-マンデル酸 Usage And Synthesis |
| 外観 | 白色,結晶～結晶性粉末 | | 溶解性 | 水及びエタノールに溶けやすい。 | | 用途 | マンデル酸誘導体はいくつかのスキンケア日用品に含まれており、他の生体物質分子を産生する際の中間体であり、分析試薬や染料工業の前駆体として利用される。
| | 用途 | アミン類の光学分割剤。 | | 化学的特性 | white to light yellow crystal powde | | 使用 | (R)-(?)-Mandelic acid can be used:
- As a chiral acid in the separation of diastereomeric salts for the synthesis of chiral pyridoindole based building block.
- In the study of chiral acid selectivity of poly(3,4-ethylenedioxythiophene) (PEDOT) based chiral conducting?polymers.
| | 使用 | (R)-(-)-Mandelic acid, is used as a antiseptic ingredient particularly against urinary tract infections.Mandelic acid and its derivatives are used to apply the dual activities as an antibacterial agent and as an antiaging agent. It is used as an intermediate for the synthesis of target molecules for other applications. | | 使用 | Antiseptic (urinary). | | 定義 | ChEBI: (R)-mandelic acid is the (R)-enantiomer of mandelic acid. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a (R)-mandelate. It is an enantiomer of a (S)-mandelic acid. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 33, p. 2565, 1968 DOI: 10.1021/jo01270a105
Synthetic Communications, 18, p. 2141, 1988 DOI: 10.1080/00397918808068285 | | 一般的な説明 | (R)-(-)-Mandelic acid, a chiral resolving agent, is also used as a building block to synthesize pharmaceutical drugs such as penicillin and cephalosporin. It can be synthesized from (R,S)-mandelonitrile with high yield and enantioselectivity using nitrilase enzyme. | | 燃焼性と爆発性 | Non flammable | | 純化方法 | Purify the mandelic acids by recrystallisation from H2O, *C6H6 or CHCl3. [Roger J Chem Soc 2168 1932,Jamison & Turner J Chem Soc 611 1942.] They have solubilities in H2O of ca 11% at 25o. [Banks & Davies J Chem Soc 73 1938.] The S-benzylisothiuronium salts has m 180o (from H2O) and [] D 25 (+) and (-) 57o (c20, EtOH) [El Masri et al. Biochem J 68 199 1958]. [Beilstein 10 IV 564.] |
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