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| 化学名: | シアノ酢酸メチル | | 英語化学名: | Methyl cyanoacetate | | 别名: | Methyl cyanoethanoate;methyl2-cyanoacetate;methylcyanoethanoate;Methylester kyseliny kyanoctove;methylesterkyselinykyanoctove;USAF kf-22;usafkf-22;Aceticacid,cyano-,methylester | | CAS番号: | 105-34-0 | | 分子式: | C4H5NO2 | | 分子量: | 99.09 | | EINECS: | 203-288-8 | | カテゴリ情報: | organic chemical;Piperazines;C2 to C5;Carbonyl Compounds;Esters | | Mol File: | 105-34-0.mol |  |
| 主な危険性 | Xi | | Sフレーズ | 24/25 | | WGK Germany | 1 | | RTECS 番号 | AG4375000 | | Hazard Note | Irritant | | TSCA | Yes | | HSコード | 29269095 | | 毒性 | guinea pig,LDLo,skin,400mg/kg (400mg/kg),"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 920, 1986. |
| | シアノ酢酸メチル Usage And Synthesis |
| 外観 | 無色～わずかにうすい黄色, 澄明の液体 | | 溶解性 | 水, エタノール, アセトンに混和。エタノール、アセトン及び水に溶ける。 | | 化学的特性 | clear colorless to very slighlty yellow liquid | | 使用 | pharmaceutical intermediate | | 使用 | Methyl cyanoacetate is an intermediate in the preparation of α-cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic acid dye. It is used as UV absorber or stabiliser, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. | | 定義 | ChEBI: Methyl cyanoacetate is an alkyl cyanoacetate ester. | | 一般的な説明 | Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Kn?venagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α-cyanocinnamic esters. | | 純化方法 | Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.] |
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