| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Dienogest-d8
CAS:2376035-92-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Dienogest-d8
CAS:2376035-92-4
Purity:>95% Package:1mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Dienogest-d8
CAS:2376035-92-4
|
| Company Name: |
SynZeal Research Pvt Ltd
|
| Tel: |
+1 226-802-2078 |
| Email: |
standards@synzeal.com |
| Products Intro: |
Product Name:Dienogest D8
CAS:2376035-92-4
|
|
| | Dienogest-d8 Basic information |
| Product Name: | Dienogest-d8 | | Synonyms: | Dienogest-d8;17α-hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile-2,2,4,8,11,11,20,20-d8 | | CAS: | 2376035-92-4 | | MF: | C20H25NO2 | | MW: | 311.43 | | EINECS: | | | Product Categories: | | | Mol File: | 2376035-92-4.mol |  |
| | Dienogest-d8 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Chloroform: slightly soluble,Methanol: slightly, sonicated | | form | A solid |
| | Dienogest-d8 Usage And Synthesis |
| Biological Activity | Dienogest-d8 is intended for use as an internal standard for the quantification of dienogest by GC- or LC-MS. Dienogest is a synthetic progestin and progesterone receptor (PR) agonist (EC50s = 3.4-10.5 nM in transactivation assays).1 It is selective for PR over estrogen receptor α (ERα) and ERβ, as well as glucocorticoid and mineralocorticoid receptors (EC50s = >3,000 nM for all), as well as sex hormone-binding globulin (SHBG) and cortisol-binding globulin (CBG; IC50s = 900-950 and 7,970 nM, respectively, in radioligand binding assays). It also inhibits dihydrotestosterone-induced transactivation of the androgen receptor (EC50s = 420.6-775 nM). Dienogest (0.1, 0.3, and 1 mg/kg per day for 21 days, p.o.) reduces lesion formation in a rat model of endometriosis.2 It reduces 17β-estradiol benzoate-dependent tumor growth in an MCF-7 ovariectomized mouse xenograft model when administered at doses of 0.1 and 1 mg/kg per day for 28 days.3 Formulations containing dienogest in combination with estradiol valerate have been used as contraceptives. | | References | 1.Sasagawa, S., Shimizu, Y., Kami, H., et al.Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profileSteroids73(2)222-231(2008)
2.Katsuki, Y., Takano, Y., Futamura, Y., et al.Effects of dienogest, a synthetic steroid, on experimental endometriosis in ratsEur. J. Endocrinol.138(2)216-226(1998)
3.Katsuki, Y., Shibutani, Y., Aoki, D., et al.Dienogest, a novel synthetic steroid, overcomes hormone-dependent cancer in a different manner than progestinsCancer79(1)169-176(1997) |
| | Dienogest-d8 Preparation Products And Raw materials |
|